Signal Synq™ Hydrating Serum
Skin loses signals over time. Signal Synq™ helps keep them talking. A face + body skin longevity treatment built on vitamin A (retinyl linoleate), plant-derived PDRN and a peptide system — to support visible firmness, smoother texture, renewal and resilience.
First 100 orders of the 1 fl oz or 9 fl oz get a free Mini Bar Exfolis scrub in the box. No code needed.
Is it for your skin?
The science
Key ingredients
How to use
NOW
FEEL IT
An immediate smoothing and tightening effect you can feel on application.
NEXT
HYDRATION + BARRIER
Hydration and barrier support help skin feel fuller, smoother and more resilient.
OVER TIME
RENEW · REPAIR · STRUCTURE
Vitamin A + PDRN + peptides support renewal, repair and structure where aging becomes visible.
Mini Bar Signal Synq Hydrating Serum
TRAVEL SIZE · $18 Same Signal Synq formula, 0.3 fl oz. For travel or trying it first.
$27.00
THREE DIFFERENT
PATHWAYS.
ONE FORMULA.
Three actives, each with its own body of evidence: the suppliers' own human and lab testing for vitamin A (LinoRet-AF®), PDRN, peptides and the tightening complex. None are tests of finished Signal — and we'd rather tell you that than pretend otherwise.
Supplier split-face human study: 24 people, ages 22–55, applied 2% LinoRet-AF® (retinyl linoleate) twice daily for 8 weeks against placebo. At 8 weeks the LinoRet-AF® side reduced wrinkle size 136% more than the placebo side (191% more at 4 weeks). Skin hydration rose 7.56%. Skin imperfections were visibly reduced at 4 weeks (Antera 3D imaging). In a separate phototoxicity test (20% LinoRet-AF®, single application, then UVA), 33 of 33 subjects showed no phototoxic reaction.
A natural film-forming complex gives Signal the tightening you feel right away, and the hydration was still +26% eight hours later. Supplier in-vivo testing of the complex, at the level used in Signal.
+109% Collagen XIII and +47% Collagen IV expression in the same test¹ — collagen support across multiple layers of the skin.
8.4% average lifting effect after 28 days, up to 46%² — human study of the same PDRN at 2%, 32 people age 50+.
Up to 86% reduction in medium wrinkle area and up to 98% reduction in deep wrinkle area — best individual results. 24 women ages 42–66, daily use for 2 months.
*Vitamin A: supplier split-face human study of 2% LinoRet-AF® (retinyl linoleate), 24 subjects ages 22–55, twice daily for 8 weeks vs. placebo; wrinkle-size reduction 136% greater than placebo at 8 weeks (191% greater at 4 weeks); skin hydration +7.56% at 8 weeks. Phototoxicity: separate supplier test of 20% LinoRet-AF®, 33 subjects, single application followed by UVA exposure; 33 of 33 showed no reaction. Results are ingredient-level research and not a clinical study of Signal Synq™. Tightening: supplier in-vivo testing of the film-forming complex at 3%; firmness +23% at 24 hours, moisturization +37% immediately and +26% at 8 hours. ¹ PDRN: supplier in-vitro study on reconstructed human skin treated with 2% vegan, marine-derived PDRN from Chlorella vulgaris (BluFermis-PDRN), the same use level in Signal Synq™; collagen XXIII, XIII and IV gene expression vs. untreated. ² Supplier in-vivo study of BluFermis-PDRN at 2%; 32 people age 50+, face, neck and décolleté twice daily for 28 days; average lifting effect +8.4%, best individual +46%. Peptides: supplier clinical study of Dermaxyl® CL at 2%, the same use level in Signal Synq™; 24 women ages 42–66, daily use for 2 months; wrinkle density −34% (average), medium and deep wrinkle area up to −86% and −98% (best individual results). Results describe the ingredient technologies, not the finished Signal Synq™ formula. Results vary.
THIS IS WHAT
WE MEAN.
Jen, Urthy's founder, on her own skin. Phone photos against the same wall in the same light, bare skin, no retouching. Zoomed in so you can see the texture, not the face.
The fine cross-hatch between the horizontal lines is where crepey texture lives. At Day 21 it reads smoother and less papery. The deep horizontal lines are still there.
The etched, crinkled texture across the cheek and beside the mouth is visibly softer and the surface looks plumper. Age spots essentially unchanged — this isn't a brightening routine.
Same side, same angle. Fine lines fanning from the nose toward the jaw look shallower; skin tone reads more even. The smile line is still there — as expected.
Left forearm: regular lotion. Right forearm: Signal. Same day, same person. This is the immediate tightening you can feel — the long-term actives work underneath it.
Founder's personal photos, not a clinical study. Day 0 photos taken late August 2026, Day 21 photos 9/16/26. Routine for those 21 days: Signal Synq™ Hydrating Serum, Clerra and Ekoa Longevity Oil, morning and night. Arm photos taken the same day: Signal on one forearm, regular lotion on the other. Individual results vary.
WHY I CALLED IT
SIGNAL.
Under two minutes, in my own words — what skin stops doing over time, why Signal is built for your face and the skin below it, and what vitamin A, PDRN and peptides are actually there to do.
THREE ACTIVES.
THREE VERY
DIFFERENT JOBS.
Not three trendy actives doing roughly the same thing. Each one takes a different way into aging skin — and everything else in the formula is there to help these three work.
Retinyl linoleate. Vitamin A, the gentler way.
LinoRet-AF® is retinyl linoleate — vitamin A bonded to linoleic acid, an omega-6 fatty acid skin already knows. Skin converts it to retinol gradually, so it supports cell turnover and collagen-related pathways with far less of the irritation that makes people quit retinoids.
Smoother texture. Softer-looking lines. More even-looking skin. Firmer-looking skin over time.
In the supplier's split-face human study, 24 people ages 22–55 applied 2% LinoRet-AF® twice daily for 8 weeks, placebo on the other side. At 8 weeks the LinoRet-AF® side showed 136% greater wrinkle-size reduction than placebo (191% greater at 4 weeks), and skin hydration rose 7.56%. Skin imperfections were visibly reduced by week 4 (Antera 3D imaging).
In a separate phototoxicity test — 20% LinoRet-AF®, single application to the back followed by UVA exposure — 33 of 33 subjects showed no phototoxic reaction.
Regenerative signaling — not exfoliation.
PDRN (polydeoxyribonucleotide) is a cellular signaling ingredient that supports skin renewal, tissue regeneration and resilience. Ours is marine-derived from Chlorella microalgae — not salmon — and it helps strengthen and rebuild collagen across multiple layers of the skin.
Skin that looks tighter, stronger and better able to bounce back — especially where laxity and crepey texture show up first.
In the supplier's in-vitro study on reconstructed human skin, 2% of the chlorella-derived PDRN in Signal — the same use level Signal uses — increased expression of Collagen XXIII by 155%, Collagen XIII by 109% and Collagen IV by 47%. Different collagens live at different depths; that spread is what "rebuild across layers" means.
The same PDRN at 2% was tested in 32 people age 50+ with sagging skin and wrinkles on the face, neck and décolleté. After 28 days of twice-daily use: average lifting effect +8.4%, best individual result +46%.
Ingredient research — not a test of finished Signal.
A peptide complex chosen for structure, not for the label.
Dermaxyl® CL is an anti-aging peptide complex designed to support skin's structural matrix and visibly improve the appearance of wrinkles, firmness and elasticity. Its active peptide is Palmitoyl Hexapeptide-12 — the matrix that helps skin hold its shape.
A firmer, smoother-looking surface and support for the structure underneath it.
In the supplier's clinical study, 24 women ages 42–66 used a formula with 2% Dermaxyl® — the same use level in Signal — daily for two months: wrinkle density −34%. Image analysis found reductions of up to 86% in the area occupied by medium wrinkles and up to 98% for deep wrinkles — those two are best individual results, not averages.
A 2025 peer-reviewed study showed Palmitoyl Hexapeptide-12 penetrates the stratum corneum and epidermis and helps strengthen and repair the skin barrier in full-thickness human skin models.
Study results describe research on the individual ingredient or technology (peer-reviewed or supplier data, as labeled) and are not clinical testing of the finished Signal Synq™ formula. Results vary.
MULTIPLE SIGNALS.WORKING IN SYNQ.
Skin doesn't age through one pathway. Renewal slows. Structural proteins change. Recovery gets less efficient. Cellular energy changes. Skin loses water more easily. So we don't ask one ingredient to fix everything.
VITAMIN A SIGNALS RENEWAL.
Supports cellular turnover and visible remodeling.
PDRN SUPPORTS REGENERATION.
Supports regenerative signaling, collagen and dermal recovery.
PEPTIDES SUPPORT STRUCTURE.
Support the structural matrix behind firmness and elasticity.
THE REST HELPS THEM LAND.
Every other ingredient in the formula is engineered to help those signals land — and be heard.
THE THREE HEROES
DON'T WORK ALONE.
3 powerhouse actives. 5+ longevity technologies. One formula. Under the hood, two more technologies chosen to make the signals land — in a base that handles hydration and barrier while they work.
Supplier testing at the same 3% Signal uses: firmness +23% after 24 hours; moisturization +37% immediately and still +26% after eight hours.
In vitro: NAD+/NADH production +76%; in aged fibroblasts, collagen synthesis +19% and cell density +7%. In a 42-day study of 50 adults ages 50–70, wrinkle surface area was significantly reduced, with effects still measured seven days after treatment ended.
Study results describe research on the individual ingredient or technology (peer-reviewed or supplier data, as labeled) and are not clinical testing of the finished Signal Synq™ formula. Results vary.
FACE CARE HAS HAD
A VERY GOOD PUBLICIST.
THE REST OF YOUR SKIN HAS BEEN AGING TOO. FACE → NECK → CHEST → HANDS → ARMS → BODY. Your chest is skin. Your neck is skin. Your arms are skin. We didn't take a face serum and say "you can put it on your arms too." Signal was built as one treatment for all of it — and the research on its technologies doesn't stop at the jaw either.
32 people age 50+ with sagging, wrinkled neck and décolleté skin. The PDRN technology in Signal, at the concentration Signal uses, twice daily on face, neck and décolleté.
REGULAR LOTIONSIGNALSignal's peptide system has been shown to penetrate and support the barrier in full-thickness human skin. Its wrinkle results come from a facial study; no one has run an arm trial yet, and we won't pretend otherwise.
*PDRN: supplier clinical, 32 people 50+, 2% PDRN complex on face, neck and décolleté twice daily for 28 days, Cutometer measurement; average lifting effect +8.4%, best individual +46%. Peptides: ex-vivo full-thickness human skin, not a body wear study (ACS Appl Bio Mater 2025). Forearm photo: one person, one day, not a study. Results describe the ingredient technologies, not the finished Signal Synq™ formula. Results vary.
THE GOAL ISN'T YOUNGER SKIN.IT'S SKIN THAT KEEPS WORKING.
We're not trying to stop birthdays. We're trying to support the things skin needs to keep doing well as time changes how it functions.
RENEW
Turn over efficiently.
REPAIR
Recover and regenerate.
MAINTAIN STRUCTURE
Support collagen, elasticity and firmness.
HOLD WATER
Maintain hydration and barrier function.
RESPOND
Keep cellular signaling and energy pathways working.
APPLY AFTER
CLEANSING.
Smooth 1–2 pumps over clean skin, morning and night. Face, neck, chest, hands — anywhere skin feels thinner, drier or less firm. After cleansing, before oil or balm. Signal contains vitamin A (retinyl linoleate), a gentle form: if your skin is new to vitamin A, start every other night for the first two weeks. Give it a full 30 days.
Signal is your hydrator — there's no separate moisturizer to buy. It contains vitamin A as retinyl linoleate, a gentle form: if your skin is new to vitamin A, start every other night for two weeks. Give it a full 30 days.
