Signal Synq Skin Longevity Treatment
There's power inside.
$83.00
FACE + BODY
RETINAL + PDRN + PEPTIDES. Built to change what time changes.
Firmness. Crepey texture. Wrinkles. One treatment for the skin on your face and the skin below it. Feel it today. See it in weeks. Built for the long run.
NOW
FEEL IT
An immediate smoothing and tightening effect you can feel on application.
NEXT
HYDRATION + BARRIER
Hydration and barrier support help skin feel fuller, smoother and more resilient.
OVER TIME
RENEW · REPAIR · STRUCTURE
Retinal + PDRN + peptides support renewal, repair and structure where aging becomes visible.
THREE DIFFERENT
PATHWAYS.
ONE FORMULA.
Three actives, three separate bodies of evidence. Retinal and PDRN numbers come from independent, peer-reviewed human studies of those ingredient technologies. The peptide number comes from the supplier's clinical study of the peptide complex. None are tests of finished Signal — and we'd rather tell you that than pretend otherwise.
Same study: significant gains in dermal density, elasticity and viscoelasticity across the face. Separate 3-month trial: 95% of participants showed overall photoaging improvement.
Randomized, double-blind split-face trial. About 2× retinol's improvement in dermal thickness, density and periocular wrinkles; 1.8× in elasticity and firmness.
24 women ages 42–66, daily use for 2 months. "Up to" = best individual results; the average across all women was −34% wrinkle density. Supplier clinical study of the complex behind Signal's Palmitoyl Hexapeptide-12 system.
*Retinal: 24-week split-face study, 56 women, stabilized 0.1% retinaldehyde; median total wrinkle length in the measured left-forehead region, a regional instrument measurement — not "71% fewer wrinkles everywhere" (PMC12928007). PDRN: randomized, double-blind, split-face trial, 0.1% topical PDRN vs 0.1% retinol, 28 days, n=31 (PLOS ONE 2026, PMC13353946). Peptides: supplier clinical study of the peptide complex, 2% for 2 months, 24 women ages 42–66. Results describe the ingredient technologies, not the finished Signal Synq™ formula. Results vary.
THIS IS WHAT
WE MEAN.
Jen, Urthy's founder, on her own skin. Phone photos, bare skin, no retouching. Zoomed in so you can see the texture, not the lighting.
BEFORE
9/1/26The fine cross-hatch between the horizontal lines is where crepey texture lives. It reads smoother and less papery. The deep horizontal lines are still there.
BEFORE
9/1/26Fewer fine etched lines across the cheek. Pigment and age spots essentially unchanged — Signal isn't a brightening treatment.
BEFORE
9/1/26Fine lines around the mouth look softened and the surface smoother. Expression lines and nasolabial folds are still present — as expected.
REGULAR LOTION
SIGNALLeft forearm: regular lotion. Right forearm: Signal. Same day, same person. This is the immediate tightening you can feel — the long-term actives work underneath it.
Founder's personal photos, not a clinical study. Older photos taken 2024–early 2025; recent photos 9/1/26. Arm photos taken the same day: Signal on one forearm, regular lotion on the other. Individual results vary.
WHY I CALLED IT
SIGNAL.
A minute and a half, in my own words — what skin stops doing over time, why Signal is built for your face and the skin below it, and what retinal, PDRN and peptides are actually there to do.
THREE ACTIVES.
THREE VERY
DIFFERENT JOBS.
Not three trendy actives doing roughly the same thing. Each one takes a different way into aging skin — and everything else in the formula is there to help these three work.
Not a retinoid alternative. Not retinol. Retinal.
Retinaldehyde is the form of vitamin A one step closer to what skin actually uses. It supports cell turnover and collagen-related pathways — and unlike most "retinol alternatives," it has randomized human clinical research behind it.
Smoother texture. Softer-looking lines. More even-looking skin. Firmer-looking skin over time.
In a 24-week split-face study of 56 women using stabilized retinal, median wrinkle length in the measured forehead region fell 71.1% and chin wrinkle length 28.5% with 0.1% retinal, alongside significant improvements in dermal density, elasticity and viscoelasticity. Regional instrument measurements — not "71% fewer wrinkles everywhere."
In a randomized, double-blind controlled trial of 0.1% retinal, 95% of participants showed overall improvement in photoaging after three months, with skin texture +13.7%, hydration +10.2% and water loss through the skin −14.5%.
In a randomized split-face trial, retinal and retinol were compared head-to-head at the same concentrations for eight weeks. Retinal significantly improved wrinkles, hydration, elasticity and facial contour — and outperformed retinol on nearly every objective measure.
The stabilized retinal technology in Signal showed statistically significant improvement in crow's feet, fine lines, skin-tone evenness, photodamage and visual + tactile smoothness in third-party clinical grading.
Regenerative signaling — not exfoliation.
PDRN (polydeoxyribonucleotide) is a cellular signaling ingredient that supports skin renewal, tissue regeneration and resilience. Ours is plant-derived, not salmon. And the human testing on it wasn't just on the face.
Skin that looks tighter, stronger and better able to bounce back — especially where laxity and crepey texture show up first.
A 2026 peer-reviewed study (PLOS ONE) tested topical PDRN in photodamaged human skin: in a randomized, double-blind, split-face trial, 0.1% PDRN was compared directly against 0.1% retinol for 28 days. Crow's-feet wrinkle area and count fell 20–23% with PDRN versus 6–7% with retinol, with roughly 2× the improvement in dermal thickness, dermal density and periocular wrinkles and 1.8× in elasticity and firmness. Underneath the result, PDRN activated repair pathways in fibroblasts and increased collagen and elastic-fiber-associated proteins in UV-damaged skin models. Independent evidence for topical PDRN as a technology — not a test of Signal's specific PDRN.
The PDRN technology used in Signal was tested in 32 people age 50+ with sagging skin and wrinkles on the neck and décolleté: 28 days of twice-daily use produced an average 8.4% decrease in skin deformation — a measured tightening effect — with improvement as high as 46% in individual subjects. In reconstructed human skin it increased expression of a type-I collagen gene; fibroblast testing found increased collagen synthesis.
A peptide chosen for structure, not for the label.
Signal uses a Palmitoyl Hexapeptide-12 peptide system selected specifically for wrinkles, elasticity and structural support — the matrix that helps skin hold its shape.
A firmer, smoother-looking surface and support for the structure underneath it.
In the supplier's clinical study of the peptide complex behind Signal's peptide system, 24 women ages 42–66 used a formula with 2% of the complex daily for two months: wrinkle density −34%. Deeper analysis found reductions of up to 86% in the surface occupied by medium-depth wrinkles and up to 98% for deep wrinkles.
A 2025 peer-reviewed study showed Palmitoyl Hexapeptide-12 penetrates the stratum corneum and epidermis and helps strengthen and repair the skin barrier in full-thickness human skin models.
Study results describe research on the individual ingredient or technology (peer-reviewed or supplier data, as labeled) and are not clinical testing of the finished Signal Synq™ formula. Results vary.
MULTIPLE SIGNALS.WORKING IN SYNQ.
Skin doesn't age through one pathway. Renewal slows. Structural proteins change. Recovery gets less efficient. Cellular energy changes. Skin loses water more easily. So we don't ask one ingredient to fix everything.
RETINAL SIGNALS RENEWAL.
Supports cellular turnover and visible remodeling.
PDRN SUPPORTS REGENERATION.
Supports regenerative signaling, collagen and dermal recovery.
PEPTIDES SUPPORT STRUCTURE.
Support the structural matrix behind firmness and elasticity.
THE REST HELPS THEM LAND.
Every other ingredient in the formula is engineered to help those signals land — and be heard.
THE THREE HEROES
DON'T WORK ALONE.
3 powerhouse actives. 6+ longevity technologies. One formula. Under the hood, three more technologies chosen to make the signals land — in a base that handles hydration and barrier while they work.
Supplier testing at 3%: firmness +23% after 24 hours; moisturization +37% immediately and still +26% after eight hours.
In vitro: NAD+/NADH production +76%; in aged fibroblasts, collagen synthesis +19% and cell density +7%. In a 42-day study of 50 adults ages 50–70, wrinkle surface area was significantly reduced, with effects still measured seven days after treatment ended.
In supplier testing, 0.03% retinol plus 1% of this complex increased cell turnover 22% — close to the 25% seen with 0.1% retinol alone. Those tests used retinol, not retinal, so we make no multiplier claim about Signal.
Study results describe research on the individual ingredient or technology (peer-reviewed or supplier data, as labeled) and are not clinical testing of the finished Signal Synq™ formula. Results vary.
FACE CARE HAS HAD
A VERY GOOD PUBLICIST.
THE REST OF YOUR SKIN
HAS BEEN AGING TOO.
FACE → NECK → CHEST → HANDS → ARMS → BODY. Your chest is skin. Your neck is skin. Your arms are skin. We didn't take a face serum and say "you can put it on your arms too." Signal was built as one treatment for all of it — and the research on its technologies doesn't stop at the jaw either.
32 women applied a retinal formula to face, neck and chest for 8 weeks — 57% had sensitive skin. Retinal has also been studied on 40% of the body surface daily for two weeks with no detectable systemic absorption.
32 people age 50+ with sagging, wrinkled neck and décolleté skin. The PDRN technology in Signal, at the concentration Signal uses, twice daily on face, neck and décolleté.
REGULAR LOTIONSIGNALSignal's peptide system has been shown to penetrate and support the barrier in full-thickness human skin. Its wrinkle results come from a facial study; no one has run an arm trial yet, and we won't pretend otherwise.
*Retinal: 32 women, a 0.1% retinal formula (with peptides, ceramides and lipids) applied to face, neck and chest 3 nights a week for 8 weeks; visible chest fine lines improved 11% at week 2 and 19% at week 8 (J Drugs Dermatol 2024). Separately, retinal applied daily to 40% of body surface for 14 days produced no detectable retinal in blood and no change in circulating retinoid levels (Skin Pharmacol 1996, 10 volunteers). PDRN: supplier clinical, 32 people 50+, 2% PDRN complex on face, neck and décolleté twice daily for 28 days, Cutometer measurement; average decrease in skin deformation 8.4%, best individual subject 46%. Peptides: ex-vivo full-thickness human skin, not a body wear study (ACS Appl Bio Mater 2025). Forearm photos: founder, same day, one application of each; not a clinical test. These describe the ingredient technologies, not finished Signal Synq™. Results vary.
THE GOAL ISN'T YOUNGER SKIN.IT'S SKIN THAT KEEPS WORKING.
We're not trying to stop birthdays. We're trying to support the things skin needs to keep doing well as time changes how it functions.
RENEW
Turn over efficiently.
REPAIR
Recover and regenerate.
MAINTAIN STRUCTURE
Support collagen, elasticity and firmness.
HOLD WATER
Maintain hydration and barrier function.
RESPOND
Keep cellular signaling and energy pathways working.
SEE YOUR
CONCERN?
SO DID WE.
Skin doesn't change one thing at a time. Firmness, hydration, texture, renewal and resilience shift together. Signal was formulated to work on several at once — in one step.
APPLY AFTER
CLEANSING.
Signal is a leave-on treatment. Smooth 1–2 pumps over clean skin, morning and night — face, neck, chest, hands, anywhere skin feels thinner, drier or less firm. Layer oil or balm over it if you want more.
Signal is your hydrator — there's no separate moisturizer to buy. It contains retinal: if your skin is new to vitamin A, start every other night for two weeks. Give it a full 30 days.
THE BODY
HAS NOTES.
“Our skin changes as we get older. That is a fact of life. But that doesn't mean we are just stuck with dry, gray skin. This serum puts life back into my skin - it is truly a fabulous product. I LOVE it and cannot recommend it enough.”
“This product is the best I've ever used. Very hydrating and after 4 times using it my face has a noticeable difference. Fine lines disappearing, smooth, healthy glow. Highly recommend it!”
“This serum feels decadent! I see how my skin is just so hydrated and smooth now!”